Title |
Potential Cardiovascular Risks of Proton Pump Inhibitors in the General Population
|
---|---|
Published in |
International Heart Journal, March 2017
|
DOI | 10.1536/ihj.16-208 |
Pubmed ID | |
Authors |
Wengen Zhu, Kui Hong |
Abstract |
Proton pump inhibitors (PPIs) are the most effective gastric acid-suppressing agents and the mainstay medical therapy for a series of acid peptic diseases. In general, the safety profile of PPIs is excellent. However, with long-term drug administration, the safety and potency of PPIs has been questioned. In the cardiovascular field, drug-drug interactions related to PPIs have been identified with particular attention regarding the use of PPIs combined with clopidogrel in patients with acute coronary syndrome. Currently, cardiovascular risks from PPIs may extend from patients with coronary artery disease to the general population. This review summarizes the possible cardiovascular risks in PPI users with no history of cardiovascular diseases and discusses possible biological mechanisms. |
X Demographics
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Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 3 | 25% |
Ecuador | 1 | 8% |
Peru | 1 | 8% |
Venezuela, Bolivarian Republic of | 1 | 8% |
United States | 1 | 8% |
Unknown | 5 | 42% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 10 | 83% |
Practitioners (doctors, other healthcare professionals) | 2 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 20 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 20% |
Student > Doctoral Student | 3 | 15% |
Researcher | 3 | 15% |
Other | 2 | 10% |
Student > Bachelor | 2 | 10% |
Other | 2 | 10% |
Unknown | 4 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 55% |
Nursing and Health Professions | 2 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Arts and Humanities | 1 | 5% |
Biochemistry, Genetics and Molecular Biology | 1 | 5% |
Other | 0 | 0% |
Unknown | 4 | 20% |