Title |
Concurrent Afatinib and Whole-Brain Radiotherapy in Exon 19-del-EGFR Mutant Lung Adenocarcinoma: A Case Report and Mini Review of the Literature
|
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Published in |
Frontiers in oncology, May 2017
|
DOI | 10.3389/fonc.2017.00088 |
Pubmed ID | |
Authors |
Chukwuka Eze, Nina-Sophie Hegemann, Olarn Roengvoraphoj, Maurice Dantes, Farkhad Manapov |
Abstract |
Leptomeningeal metastases (LM) are found in approximately 3.8% of non-small cell lung cancer cases with an increased incidence in adenocarcinoma, and approximately one-third of patients will present with concomitant brain metastases. We report the case of a 50-year-old male patient with stage IV exon 19-del-EGFR mutant lung adenocarcinoma who progressed on second-generation TKI therapy with manifestation of symptomatic simultaneous diffuse brain and LM. Whole-brain radiotherapy with concurrent afatinib resulted in an almost complete regression of neurological symptoms as well as good, durable radiological response. Furthermore, treatment was well tolerated with no relevant adverse effects. |
X Demographics
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 16% |
Other | 3 | 10% |
Student > Doctoral Student | 3 | 10% |
Student > Bachelor | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Other | 5 | 16% |
Unknown | 9 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 42% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Agricultural and Biological Sciences | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Psychology | 1 | 3% |
Other | 1 | 3% |
Unknown | 12 | 39% |