Title |
Association of Changes in Mood Status and Psychosocial Well-Being with Depression During Interferon-Based Treatment for Hepatitis C
|
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Published in |
Psychiatry Investigation, May 2017
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DOI | 10.4306/pi.2017.14.3.314 |
Pubmed ID | |
Authors |
Jung-Seok Choi, Won Kim, Bo Kyung Sohn, Jun-Young Lee, Hee Yeon Jung, Sohee Oh, Sae Kyoung Joo, Hwi Young Kim, Yong Jin Jung |
Abstract |
The aims of this prospective study were to investigate temporal changes in mood status and distress level, as well as the development of depression, during pegylated interferon (PEG-IFN)-based treatment of patients with chronic hepatitis C (CHC). We also explored whether baseline demographic, psychiatric, and personality traits predicted the evolution of depression. CHC patients without depression were screened with laboratory tests; psychiatric interviews; and evaluations of mood symptoms, level of distress, and personality traits. A total of 67 treatment-naïve patients with CHC were consecutively treated with PEG-IFN-α-2a plus ribavirin for 48 (genotype 1, n=29) or 24 (genotype 2, n=38) weeks. Patients were followed prospectively every 4 weeks during the treatment period. Seven patients (10.4%) were diagnosed with major depressive disorder (MDD), and eight (11.9%) developed subsyndromal depression. Times to onset of MDD and subsyndromal depression were 6.67±5.01 and 11.11±5.58 weeks, respectively, after initiation of treatment. Patients who developed MDD had significantly increased fatigue and anxiety and poor psychological well-being during the course of treatment. Pretreatment subthreshold mood symptoms were a significant predictor of depression. An early psychiatric assessment may be helpful in improving psychological well-being in those with CHC, leading to adherence to PEG-IFN-based treatment. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 7 | 16% |
Student > Master | 6 | 14% |
Researcher | 6 | 14% |
Student > Ph. D. Student | 3 | 7% |
Student > Doctoral Student | 2 | 5% |
Other | 8 | 18% |
Unknown | 12 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 11 | 25% |
Medicine and Dentistry | 7 | 16% |
Biochemistry, Genetics and Molecular Biology | 2 | 5% |
Arts and Humanities | 1 | 2% |
Unspecified | 1 | 2% |
Other | 7 | 16% |
Unknown | 15 | 34% |