Title |
Mechanisms of copper homeostasis in bacteria
|
---|---|
Published in |
Frontiers in Cellular and Infection Microbiology, January 2013
|
DOI | 10.3389/fcimb.2013.00073 |
Pubmed ID | |
Authors |
José M. Argüello, Daniel Raimunda, Teresita Padilla-Benavides |
Abstract |
Copper is an important micronutrient required as a redox co-factor in the catalytic centers of enzymes. However, free copper is a potential hazard because of its high chemical reactivity. Consequently, organisms exert a tight control on Cu(+) transport (entry-exit) and traffic through different compartments, ensuring the homeostasis required for cuproprotein synthesis and prevention of toxic effects. Recent studies based on biochemical, bioinformatics, and metalloproteomics approaches, reveal a highly regulated system of transcriptional regulators, soluble chaperones, membrane transporters, and target cuproproteins distributed in the various bacterial compartments. As a result, new questions have emerged regarding the diversity and apparent redundancies of these components, their irregular presence in different organisms, functional interactions, and resulting system architectures. |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Mendeley readers
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India | 1 | <1% |
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Denmark | 1 | <1% |
Spain | 1 | <1% |
Unknown | 369 | 98% |
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Student > Bachelor | 60 | 16% |
Researcher | 45 | 12% |
Student > Master | 41 | 11% |
Student > Doctoral Student | 28 | 7% |
Other | 38 | 10% |
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Chemistry | 23 | 6% |
Environmental Science | 16 | 4% |
Immunology and Microbiology | 15 | 4% |
Other | 35 | 9% |
Unknown | 99 | 26% |