Title |
A Thiazole Orange Derivative Targeting the Bacterial Protein FtsZ Shows Potent Antibacterial Activity
|
---|---|
Published in |
Frontiers in Microbiology, May 2017
|
DOI | 10.3389/fmicb.2017.00855 |
Pubmed ID | |
Authors |
Ning Sun, Yu-Jing Lu, Fung-Yi Chan, Ruo-Lan Du, Yuan-yuan Zheng, Kun Zhang, Lok-Yan So, Ruben Abagyan, Chao Zhuo, Yun-Chung Leung, Kwok-Yin Wong |
Abstract |
The prevalence of multidrug resistance among clinically significant bacteria calls for the urgent development of new antibiotics with novel mechanisms of action. In this study, a new small molecule exhibiting excellent inhibition of bacterial cell division with potent antibacterial activity was discovered through cell-based screening. The compound exhibits a broad spectrum of bactericidal activity, including the methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus and NDM-1 Escherichia coli. The in vitro and in vivo results suggested that this compound disrupts the dynamic assembly of FtsZ protein and Z-ring formation through stimulating FtsZ polymerization. Moreover, this compound exhibits no activity on mammalian tubulin polymerization and shows low cytotoxicity on mammalian cells. Taken together, these findings could provide a new chemotype for development of antibacterials with FtsZ as the target. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 20% |
Student > Bachelor | 5 | 17% |
Student > Master | 4 | 13% |
Researcher | 3 | 10% |
Professor > Associate Professor | 2 | 7% |
Other | 3 | 10% |
Unknown | 7 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 20% |
Chemistry | 6 | 20% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 13% |
Agricultural and Biological Sciences | 2 | 7% |
Immunology and Microbiology | 1 | 3% |
Other | 3 | 10% |
Unknown | 8 | 27% |