Title |
Metabolic and Biochemical Stressors in Diabetic Cardiomyopathy
|
---|---|
Published in |
Frontiers in Cardiovascular Medicine, May 2017
|
DOI | 10.3389/fcvm.2017.00031 |
Pubmed ID | |
Authors |
Vasundhara Kain, Ganesh V. Halade |
Abstract |
Diabetic cardiomyopathy (DCM) or diabetes-induced cardiac dysfunction is a direct consequence of uncontrolled metabolic syndrome and is widespread in US population and worldwide. Despite of the heterogeneous and distinct features of DCM, the clinical relevance of DCM is now becoming established. DCM progresses to pathological cardiac remodeling with the higher risk of heart attack and subsequent heart failure in diabetic patients. In this review, we emphasize lipid substrate quality and the phenotypic, metabolic, and biochemical stressors of DCM in the rodent and human pathophysiology. We discuss lipoxygenase signaling in the inflammatory pathway with multiple contributing and confounding factors leading to DCM. Additionally, emerging biochemical pathways are emphasized to make progress toward therapeutic advancement to treat DCM. |
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Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Switzerland | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Scientists | 2 | 67% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 17% |
Researcher | 5 | 14% |
Student > Bachelor | 4 | 11% |
Student > Master | 4 | 11% |
Unspecified | 2 | 6% |
Other | 6 | 17% |
Unknown | 8 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 34% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Agricultural and Biological Sciences | 3 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Unspecified | 2 | 6% |
Other | 4 | 11% |
Unknown | 8 | 23% |