Title |
Elastin-Like Protein, with Statherin Derived Peptide, Controls Fluorapatite Formation and Morphology
|
---|---|
Published in |
Frontiers in Physiology, June 2017
|
DOI | 10.3389/fphys.2017.00368 |
Pubmed ID | |
Authors |
Kseniya Shuturminska, Nadezda V. Tarakina, Helena S. Azevedo, Andrew J. Bushby, Alvaro Mata, Paul Anderson, Maisoon Al-Jawad |
Abstract |
The process of enamel biomineralization is multi-step, complex and mediated by organic molecules. The lack of cells in mature enamel leaves it unable to regenerate and hence novel ways of growing enamel-like structures are currently being investigated. Recently, elastin-like protein (ELP) with the analog N-terminal sequence of statherin (STNA15-ELP) has been used to regenerate mineralized tissue. Here, the STNA15-ELP has been mineralized in constrained and unconstrained conditions in a fluoridated solution. We demonstrate that the control of STNA15-ELP delivery to the mineralizing solution can form layered ordered fluorapatite mineral, via a brushite precursor. We propose that the use of a constrained STNA15-ELP system can lead to the development of novel, bioinspired enamel therapeutics. |
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Country | Count | As % |
---|---|---|
United Kingdom | 3 | 60% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 60% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Scientists | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 31 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 29% |
Student > Postgraduate | 4 | 13% |
Student > Master | 4 | 13% |
Researcher | 3 | 10% |
Student > Bachelor | 1 | 3% |
Other | 3 | 10% |
Unknown | 7 | 23% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 19% |
Materials Science | 5 | 16% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Engineering | 2 | 6% |
Chemistry | 2 | 6% |
Other | 3 | 10% |
Unknown | 11 | 35% |