Title |
The emerging roles of ribosome biogenesis in craniofacial development
|
---|---|
Published in |
Frontiers in Physiology, January 2014
|
DOI | 10.3389/fphys.2014.00026 |
Pubmed ID | |
Authors |
Adam P. Ross, Konstantinos S. Zarbalis |
Abstract |
Neural crest cells (NCCs) are a transient, migratory cell population, which originates during neurulation at the neural folds and contributes to the majority of tissues, including the mesenchymal structures of the craniofacial skeleton. The deregulation of the complex developmental processes that guide migration, proliferation, and differentiation of NCCs may result in a wide range of pathological conditions grouped together as neurocristopathies. Recently, due to their multipotent properties neural crest stem cells have received considerable attention as a possible source for stem cell based regenerative therapies. This exciting prospect underlines the need to further explore the developmental programs that guide NCC differentiation. This review explores the particular importance of ribosome biogenesis defects in this context since a specific interface between ribosomopathies and neurocristopathies exists as evidenced by disorders such as Treacher-Collins-Franceschetti syndrome (TCS) and Diamond-Blackfan anemia (DBA). |
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Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
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Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Philippines | 1 | 1% |
United States | 1 | 1% |
Germany | 1 | 1% |
Unknown | 69 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 22% |
Researcher | 9 | 12% |
Student > Bachelor | 9 | 12% |
Student > Master | 8 | 11% |
Student > Doctoral Student | 5 | 7% |
Other | 16 | 22% |
Unknown | 10 | 14% |
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Neuroscience | 3 | 4% |
Economics, Econometrics and Finance | 1 | 1% |
Other | 3 | 4% |
Unknown | 9 | 12% |