Ian T Rossman, Lulu Lin, Katherine M Morgan, Marissa DiGiovine, Elise K Van Buskirk, Silky Kamdar, James H Millonig, Emanuel DiCicco-Bloom
Abstract
The homeobox transcription factor Engrailed2 (En2) has been studied extensively in neurodevelopment, particularly in the midbrain/hindbrain region and cerebellum, where it exhibits dynamic patterns of expression and regulates cell patterning and morphogenesis. Because of its roles in regulating cerebellar development and evidence of cerebellar pathology in autism spectrum disorder (ASD), we previously examined an ENGRAILED2 association and found evidence to support EN2 as a susceptibility gene, a finding replicated by several other investigators. However, its functions at the cell biological level remain undefined. In the mouse, En2 gene is expressed in granule neuron precursors (GNPs) just as they exit the cell cycle and begin to differentiate, raising the possibility that En2 may modulate these developmental processes.
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2016.
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#15,272,550
of 26,406,115 outputs
Outputs from Molecular Autism
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Outputs of similar age
#175,384
of 325,794 outputs
Outputs of similar age from Molecular Autism
#15
of 24 outputs
Altmetric has tracked 26,406,115 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
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