Title |
Interferon-Lambda: A Potent Regulator of Intestinal Viral Infections
|
---|---|
Published in |
Frontiers in immunology, June 2017
|
DOI | 10.3389/fimmu.2017.00749 |
Pubmed ID | |
Authors |
Sanghyun Lee, Megan T. Baldridge |
Abstract |
Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and may represent a factor that contributes to human variability in response to infection. Importantly, recombinant IFN-λ has therapeutic potential against enteric viral infections, many of which lack other effective treatments. In this mini-review, we describe recent advances regarding IFN-λ-mediated regulation of enteric viruses with important clinical relevance including rotavirus, reovirus, and norovirus. We also briefly discuss IFN-λ interactions with other cytokines important in the intestine, and how IFN-λ may play a role in regulation of intestinal viruses by the commensal microbiome. Finally, we indicate currently outstanding questions regarding IFN-λ control of enteric infections that remain to be explored to enhance our understanding of this important immune molecule. |
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Canada | 1 | 14% |
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Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
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Unknown | 117 | 100% |
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Researcher | 23 | 20% |
Student > Ph. D. Student | 20 | 17% |
Student > Doctoral Student | 12 | 10% |
Student > Master | 11 | 9% |
Student > Bachelor | 10 | 9% |
Other | 16 | 14% |
Unknown | 25 | 21% |
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Unspecified | 2 | 2% |
Other | 9 | 8% |
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