| Chapter title |
Neutrophils: The Role of Oxidative and Nitrosative Stress in Health and Disease.
|
|---|---|
| Chapter number | 117 |
| Book title |
Pulmonary Infection
|
| Published in |
Advances in experimental medicine and biology, April 2015
|
| DOI | 10.1007/5584_2015_117 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-917457-0, 978-3-31-917458-7
|
| Authors |
Manda-Handzlik, Aneta, Demkow, Urszula, Aneta Manda-Handzlik, Urszula Demkow |
| Editors |
Mieczyslaw Pokorski |
| Abstract |
Neutrophils constitute the first line of the innate immunity in humans. They employ several strategies to trap and kill microorganisms, such as phagocytosis, degranulation, and the formation of extracellular traps (NETs). It has been well documented, that generation of reactive oxygen and nitrogen species (ROS and RNS) is crucial in the life cycle of a polymorphonuclear phagocyte. These compounds due to high reactivity act as powerful antimicrobial factors in the process of pathogens clearance and can also modulate immunological response. On the other hand, excessive amount of free radicals may have detrimental effect on host tissues and markers of oxidative and nitrosative stress are detectable in many diseases. It is necessary to maintain the balance between ROS/RNS formation and removal. The review highlights our current understanding of the role of ROS and RNS produced by neutrophils in health and disease. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Russia | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 66 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 25 | 37% |
| Student > Bachelor | 9 | 13% |
| Student > Doctoral Student | 6 | 9% |
| Researcher | 6 | 9% |
| Student > Ph. D. Student | 6 | 9% |
| Other | 3 | 4% |
| Unknown | 13 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 26% |
| Agricultural and Biological Sciences | 9 | 13% |
| Immunology and Microbiology | 9 | 13% |
| Medicine and Dentistry | 6 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Other | 8 | 12% |
| Unknown | 16 | 24% |