Title |
The role of iron in anthracycline cardiotoxicity
|
---|---|
Published in |
Frontiers in Pharmacology, January 2014
|
DOI | 10.3389/fphar.2014.00025 |
Pubmed ID | |
Authors |
Elena Gammella, Federica Maccarinelli, Paolo Buratti, Stefania Recalcati, Gaetano Cairo |
Abstract |
The clinical use of the antitumor anthracycline Doxorubicin is limited by the risk of severe cardiotoxicity. The mechanisms underlying anthracycline-dependent cardiotoxicity are multiple and remain uncompletely understood, but many observations indicate that interactions with cellular iron metabolism are important. Convincing evidence showing that iron plays a role in Doxorubicin cardiotoxicity is provided by the protecting efficacy of iron chelation in patients and experimental models, and studies showing that iron overload exacerbates the cardiotoxic effects of the drug, but the underlying molecular mechanisms remain to be completely characterized. Since anthracyclines generate reactive oxygen species, increased iron-catalyzed formation of free radicals appears an obvious explanation for the aggravating role of iron in Doxorubicin cardiotoxicity, but antioxidants did not offer protection in clinical settings. Moreover, how the interaction between reactive oxygen species and iron damages heart cells exposed to Doxorubicin is still unclear. This review discusses the pathogenic role of the disruption of iron homeostasis in Doxorubicin-mediated cardiotoxicity in the context of current and future pharmacologic approaches to cardioprotection. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Chile | 1 | <1% |
United States | 1 | <1% |
India | 1 | <1% |
Unknown | 147 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 31 | 21% |
Student > Master | 20 | 13% |
Researcher | 17 | 11% |
Student > Bachelor | 14 | 9% |
Student > Postgraduate | 11 | 7% |
Other | 21 | 14% |
Unknown | 36 | 24% |
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Agricultural and Biological Sciences | 21 | 14% |
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Chemistry | 4 | 3% |
Other | 8 | 5% |
Unknown | 41 | 27% |