Title |
In vitro and cellular activities of the selected fruits residues for skin aging treatment
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Published in |
Anais da Academia Brasileira de Ciências, May 2017
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DOI | 10.1590/0001-3765201720160849 |
Pubmed ID | |
Authors |
NATTAYA LOURITH, MAYUREE KANLAYAVATTANAKUL, PUXVADEE CHAIKUL, CHAISAK CHANSRINIYOM, PICHAPORN BUNWATCHARAPHANSAKUN |
Abstract |
Peel extracts of litchi and rambutan, and that of tamarind seed coat were investigated in relation to their utility in skin-aging treatments. Standardized extracts of tamarind were significantly (p < 0.05) more efficient at O2 •- scavenging (IC50 = 27.44 ± 0.09) than those of litchi and rambutan (IC50 = 29.57 ± 0.30 and 39.49 ± 0.52 μg/ml, respectively) and the quercetin standard (IC50 = 31.88 ± 0.15 μg/ml). Litchi extract proved significantly (p < 0.05) more effective for elastase and collagenase inhibition (88.29 ± 0.25% and 79.46 ± 0.92%, respectively) than tamarind (35.43 ± 0.68% and 57.69 ± 5.97%) or rambutan (31.08 ± 0.38% and 53.99 ± 6.18%). All extracts were safe to human skin fibroblasts and inhibit MMP-2, with litchi extract showing significantly (p < 0.01) enhanced inhibition over the standard, vitamin C (23.75 ± 2.74% and 10.42 ± 5.91% at 0.05 mg/ml, respectively). Extracts suppress melanin production in B16F10 melanoma cells through inhibition of tyrosinase and TRP-2, with litchi extract being the most potent, even more so than kojic acid (standard). These results highlight the potential for adding value to agro-industrial waste, as the basis for the sustainable production of innovative, safe, anti-aging cosmetic products. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 9% |
Student > Bachelor | 4 | 9% |
Researcher | 4 | 9% |
Lecturer | 2 | 5% |
Other | 2 | 5% |
Other | 5 | 12% |
Unknown | 22 | 51% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 14% |
Biochemistry, Genetics and Molecular Biology | 4 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 9% |
Engineering | 2 | 5% |
Immunology and Microbiology | 1 | 2% |
Other | 3 | 7% |
Unknown | 23 | 53% |