Title |
Th17 Polarization under Hypoxia Results in Increased IL-10 Production in a Pathogen-Independent Manner
|
---|---|
Published in |
Frontiers in immunology, June 2017
|
DOI | 10.3389/fimmu.2017.00698 |
Pubmed ID | |
Authors |
Roman Volchenkov, Vegard Nygaard, Zeynep Sener, Bjørn Steen Skålhegg |
Abstract |
The IL-17-producing CD4(+) T helper cell (Th17) differentiation is affected by stimulation of the aryl hydrocarbon receptor (AhR) pathway and by hypoxia-inducible factor 1 alpha (HIF-1α). In some cases, Th17 become non-pathogenic and produce IL-10. However, the initiating events triggering this phenotype are yet to be fully understood. Here, we show that such cells may be differentiated at low oxygen and regardless of AhR ligand treatment such as cigarette smoke extract. Hypoxia led to marked alterations of the transcriptome of IL-10-producing Th17 cells affecting genes involved in metabolic, anti-apoptotic, cell cycle, and T cell functional pathways. Moreover, we show that oxygen regulates the expression of CD52, which is a cell surface protein that has been shown to suppress the activation of other T cells upon release. Taken together, these findings suggest a novel ability for Th17 cells to regulate immune responses in vivo in an oxygen-dependent fashion. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 6 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 50% |
Scientists | 2 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 41 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 22% |
Researcher | 5 | 12% |
Student > Bachelor | 5 | 12% |
Student > Master | 5 | 12% |
Student > Doctoral Student | 1 | 2% |
Other | 5 | 12% |
Unknown | 11 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 20% |
Immunology and Microbiology | 8 | 20% |
Medicine and Dentistry | 5 | 12% |
Biochemistry, Genetics and Molecular Biology | 4 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 10% |
Unknown | 11 | 27% |