Title |
Growth factors in synaptic function
|
---|---|
Published in |
Frontiers in Synaptic Neuroscience, January 2013
|
DOI | 10.3389/fnsyn.2013.00006 |
Pubmed ID | |
Authors |
Vivian Y. Poon, Sojoong Choi, Mikyoung Park |
Abstract |
Synapses are increasingly recognized as key structures that malfunction in disorders like schizophrenia, mental retardation, and neurodegenerative diseases. The importance and complexity of the synapse has fuelled research into the molecular mechanisms underlying synaptogenesis, synaptic transmission, and plasticity. In this regard, neurotrophic factors such as netrin, Wnt, transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α), and others have gained prominence for their ability to regulate synaptic function. Several of these factors were first implicated in neuroprotection, neuronal growth, and axon guidance. However, their roles in synaptic development and function have become increasingly clear, and the downstream signaling pathways employed by these factors have begun to be elucidated. In this review, we will address the role of these factors and their downstream effectors in synaptic function in vivo and in cultured neurons. |
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United Kingdom | 2 | 1% |
France | 1 | <1% |
Canada | 1 | <1% |
Brazil | 1 | <1% |
Unknown | 130 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 36 | 27% |
Researcher | 27 | 20% |
Student > Master | 12 | 9% |
Student > Doctoral Student | 11 | 8% |
Student > Bachelor | 10 | 7% |
Other | 22 | 16% |
Unknown | 17 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 48 | 36% |
Neuroscience | 28 | 21% |
Biochemistry, Genetics and Molecular Biology | 15 | 11% |
Medicine and Dentistry | 10 | 7% |
Psychology | 5 | 4% |
Other | 11 | 8% |
Unknown | 18 | 13% |