Wen-Ya Ding, Yan-Hua Li, He Lian, Xiao-Yu Ai, Yu-Lin Zhao, Yan-Bei Yang, Qiang Han, Xin Liu, Xue-Ying Chen, Zhonggui He
Abstract
Streptococcus suis is one of the most important swine pathogens, which can cause persistent infection by forming biofilms. In this study, sub-minimum inhibitory concentration (sub-MIC) of rhubarb water extracts were found to inhibit biofilm formation. Two-component signal transduction systems (TCSs), transcriptional regulators, and DNA binding proteins were compared under two conditions: (1) cells treated with sub-MIC rhubarb water extracts and (2) untreated cells. Using an isobaric tags for relative and absolute quantitation (iTRAQ) strategy, we found that TCSs constituent proteins of histidine kinase and response regulator were significantly down-regulated. This down-regulation can affect the transfer of information during biofilm formation. The transcriptional regulators and DNA binding proteins that can interact with TCSs and interrupt gene transcription were also significantly altered. For these reasons, the levels of protein expressions varied in different parts of the treated vs. untreated cells. In summary, rhubarb water extracts might serve as potential inhibitor for the control of S. suis biofilm formation. The change in TCSs, transcriptional regulators, and DNA binding proteins may be important factors in S. suis biofilm inhibition.
Pharmacology, Toxicology and Pharmaceutical Science
3
17%
Biochemistry, Genetics and Molecular Biology
3
17%
Unspecified
2
11%
Veterinary Science and Veterinary Medicine
1
6%
Agricultural and Biological Sciences
1
6%
Other
2
11%
Unknown
6
33%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2017.
All research outputs
#18,559,907
of 22,986,950 outputs
Outputs from Frontiers in Pharmacology
#8,332
of 16,272 outputs
Outputs of similar age
#239,507
of 313,004 outputs
Outputs of similar age from Frontiers in Pharmacology
#132
of 250 outputs
Altmetric has tracked 22,986,950 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 16,272 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
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We're also able to compare this research output to 250 others from the same source and published within six weeks on either side of this one. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
