Title |
Effect of Neuroinflammation on Synaptic Organization and Function in the Developing Brain: Implications for Neurodevelopmental and Neurodegenerative Disorders
|
---|---|
Published in |
Frontiers in Cellular Neuroscience, July 2017
|
DOI | 10.3389/fncel.2017.00190 |
Pubmed ID | |
Authors |
Amin Mottahedin, Maryam Ardalan, Tetyana Chumak, Ilse Riebe, Joakim Ek, Carina Mallard |
Abstract |
The brain is a plastic organ where both the intrinsic CNS milieu and extrinsic cues play important roles in shaping and wiring neural connections. The perinatal period constitutes a critical time in central nervous system development with extensive refinement of neural connections, which are highly sensitive to fetal and neonatal compromise, such as inflammatory challenges. Emerging evidence suggests that inflammatory cells in the brain such as microglia and astrocytes are pivotal in regulating synaptic structure and function. In this article, we will review the role of glia cells in synaptic physiology and pathophysiology, including microglia-mediated elimination of synapses. We propose that activation of the immune system dynamically affects synaptic organization and function in the developing brain. We will discuss the role of neuroinflammation in altered synaptic plasticity following perinatal inflammatory challenges and potential implications for neurodevelopmental and neurodegenerative disorders. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 20% |
Unknown | 8 | 80% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 60% |
Scientists | 4 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 202 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 31 | 15% |
Student > Ph. D. Student | 30 | 15% |
Researcher | 26 | 13% |
Student > Master | 18 | 9% |
Student > Doctoral Student | 9 | 4% |
Other | 32 | 16% |
Unknown | 56 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 46 | 23% |
Medicine and Dentistry | 20 | 10% |
Biochemistry, Genetics and Molecular Biology | 17 | 8% |
Agricultural and Biological Sciences | 16 | 8% |
Nursing and Health Professions | 7 | 3% |
Other | 29 | 14% |
Unknown | 67 | 33% |