Title |
Disrupting neuronal transmission: mechanism of DBS?
|
---|---|
Published in |
Frontiers in Systems Neuroscience, March 2014
|
DOI | 10.3389/fnsys.2014.00033 |
Pubmed ID | |
Authors |
Satomi Chiken, Atsushi Nambu |
Abstract |
Applying high-frequency stimulation (HFS) to deep brain structure, known as deep brain stimulation (DBS), has now been recognized an effective therapeutic option for a wide range of neurological and psychiatric disorders. DBS targeting the basal ganglia thalamo-cortical loop, especially the internal segment of the globus pallidus (GPi), subthalamic nucleus (STN) and thalamus, has been widely employed as a successful surgical therapy for movement disorders, such as Parkinson's disease, dystonia and tremor. However, the neurophysiological mechanism underling the action of DBS remains unclear and is still under debate: does DBS inhibit or excite local neuronal elements? In this review, we will examine this question and propose the alternative interpretation: DBS dissociates inputs and outputs, resulting in disruption of abnormal signal transmission. |
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