Title |
Loneliness in Relation to Depression: The Moderating Influence of a Polymorphism of the Brain Derived Neurotrophic Factor Gene on Self-efficacy and Coping Strategies
|
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Published in |
Frontiers in Psychology, July 2017
|
DOI | 10.3389/fpsyg.2017.01224 |
Pubmed ID | |
Authors |
Marc Bedard, Robbie Woods, Carly Crump, Hymie Anisman |
Abstract |
Disturbances of brain derived neurotrophic factor (BDNF) signaling, which may occur among those with a polymorphism of the Val66Met gene, comprising a Met substitution for the Val allele, may be associated with depressive cognitions. However, presumed elevated BDNF levels among individuals with the Val/Val genotype, might confer increased responsivity to contextual challenges, thus fostering vulnerability to depression. In Study 1, among undergraduate students (N = 252), increased loneliness perceptions were accompanied with depressive symptoms. This relationship was moderated by self-efficacy and BDNF genotype, such that when individuals appraised high self-efficacy, those with the Val/Val genotype, compared to Met carriers, reported greater depression scores when they perceived feeling lonely. Study 2 revealed that among undergraduate students (N = 178), lower depressive scores were associated with increased problem-focused coping among Val/Val individuals, but not Met carriers. Moreover, with increased perceived loneliness, Val/Val carriers endorsed lower problem-focused coping. Findings suggest that Val/Val individuals may have adverse neurocognitive vulnerability to loneliness experiences. |
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Country | Count | As % |
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United States | 1 | 14% |
Unknown | 6 | 86% |
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Members of the public | 6 | 86% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
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Unknown | 24 | 100% |
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Researcher | 4 | 17% |
Student > Master | 3 | 13% |
Student > Bachelor | 2 | 8% |
Other | 2 | 8% |
Other | 4 | 17% |
Unknown | 4 | 17% |
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Computer Science | 1 | 4% |
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Other | 2 | 8% |
Unknown | 7 | 29% |