Title |
Breaking Immunological Tolerance in Systemic Lupus Erythematosus
|
---|---|
Published in |
Frontiers in immunology, April 2014
|
DOI | 10.3389/fimmu.2014.00164 |
Pubmed ID | |
Authors |
Elmar Pieterse, Johan van der Vlag |
Abstract |
Systemic lupus erythematosus (SLE) is a fairly heterogeneous autoimmune disease of unknown etiology that mainly affects women in the childbearing age. SLE is a prototype type III hypersensitivity reaction in which immune complex depositions cause inflammation and tissue damage in multiple organs. Two distinct cell death pathways, apoptosis and NETosis, gained a great deal of interest among scientists, since both processes seem to be deregulated in SLE. There is growing evidence that histone modifications induced by these cell death pathways exert a central role in the induction of autoimmunity. In the current review, we discuss how abnormalities in apoptosis, NETosis, and histone modifications may lead to a break of immunological tolerance in SLE. |
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Country | Count | As % |
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Netherlands | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | <1% |
Ireland | 1 | <1% |
Unknown | 159 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 19 | 12% |
Student > Master | 17 | 11% |
Student > Bachelor | 16 | 10% |
Student > Doctoral Student | 11 | 7% |
Other | 34 | 21% |
Unknown | 34 | 21% |
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Other | 8 | 5% |
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