Title |
Role of Th1 and Th2 cells in autoimmune demyelinating disease
|
---|---|
Published in |
Brazilian Journal of Medical and Biological Research, October 1998
|
DOI | 10.1590/s0100-879x1998000100007 |
Pubmed ID | |
Authors |
L Nagelkerken |
Abstract |
Evidence is accumulating that Th1 cells play an important role in the development of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), whereas Th2 cells contribute to recovery from disease. A major determinant in the development of Th1 and Th2 cells is the type of antigen-presenting cell (APC) involved and its functional characteristics, e.g., the production of interleukin-12. Therefore, modulation of APC might interfere with the development of Th1 type responses and as such be beneficial for MS and EAE. The potential of cytokines, in particular interleukin-10, and glucocorticoids to exert a selective effect on APC, and as a consequence to affect the Th1-Th2 balance in EAE, is discussed. |
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