Title |
Interferon beta-1a-induced depression and suicidal ideation in multiple sclerosis
|
---|---|
Published in |
Arquivos de Neuro-Psiquiatria, October 2002
|
DOI | 10.1590/s0004-282x2002000500007 |
Pubmed ID | |
Authors |
Marco Aurélio Lana-Peixoto, Antônio Lúcio Teixeira, Vitor Geraldi Haase |
Abstract |
Depression and suicide have been reported in association with multiple sclerosis (MS). Some studies show that interferon beta may increase the depression rate. We report a case of depression and suicidal ideation in coincidence with the start of increased doses of interferon beta-1a and their complete reversal following the drug withdrawal. The patient was a 21-year-old man with MS and no past history of affective disorders who was given interferon beta-1a in the dose of 11 microgram three times per week. As a new relapse occurred the dose of interferon beta-1a was increased to 22 microgram three times a week. The patient then observed increased worry, irritability and a sense of discouragement as well as recurring suicidal thoughts. His mood was rapidly restored following interferon beta-1a withdrawal. This case suggests that patients with MS may develop depression and suicidal thoughts when treated with high doses of interferon beta-1a. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 2% |
Unknown | 46 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 23% |
Student > Master | 5 | 11% |
Student > Bachelor | 4 | 9% |
Student > Ph. D. Student | 4 | 9% |
Student > Doctoral Student | 3 | 6% |
Other | 10 | 21% |
Unknown | 10 | 21% |
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---|---|---|
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Psychology | 3 | 6% |
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Computer Science | 1 | 2% |
Other | 4 | 9% |
Unknown | 15 | 32% |