Title |
Comparison of Total Body Irradiation (TBI) Conditioning with Non-TBI for Autologous Stem Cell Transplantation in Newly Diagnosed or Relapsed Mature T- and NK-Cell Non-Hodgkin Lymphoma
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Published in |
Cancer Research and Treatment : Official Journal of Korean Cancer Association, May 2016
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DOI | 10.4143/crt.2015.476 |
Pubmed ID | |
Authors |
Chi Hoon Maeng, Young Hyeh Ko, Do Hoon Lim, Eun Suk Kang, Joon Young Choi, Won Seog Kim, Seok Jin Kim |
Abstract |
This retrospective study was conducted for comparison of survival outcomes and toxicities of autologous stem cell transplantation (ASCT) based on the use of total body irradiation (TBI) as a part of the conditioning regimen in patients with mature T- and NK-cell lymphomas. Patients who underwent ASCT in the upfront or salvage setting between January 2000 and December 2013 were analyzed. Patients were dichotomized according to the TBI group (n=38) and non-TBI group (n=60) based on the type of conditioning regimen for ASCT. Patients with responsive disease underwent upfront ASCT (TBI: n=16, non-TBI: n=29) whereas patients with refractory disease (TBI: n=9, non-TBI: n=12) or relapsed disease (TBI: n=13, non-TBI: n=19, Figure 1) underwent ASCT after salvage treatment. Hematologic and non-hematologic toxicities were manageable, and the median cumulative toxicity score according to Seattle criteria was estimated as 2 (range, 0-7) in both groups. No significant difference in100-day mortality was observed between the TBI (13%, 5/38) and non-TBI (12%, 12/60) groups, and most deaths were related to disease progression. There was no difference in overall and progression-free survival, however the TBI group showed a trend of better survival in upfront and salvage ASCT than the non-TBI group. However, patients with refractory disease showed the worst outcome regardless of the use of TBI. Patients who showed complete response before ASCT showed better progression-free survival than those who showed partial response. TBI could be used as an effective part of conditioning for ASCT in patients with mature T- and NK-cell lymphomas. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Other | 4 | 22% |
Researcher | 2 | 11% |
Student > Ph. D. Student | 2 | 11% |
Unspecified | 1 | 6% |
Student > Bachelor | 1 | 6% |
Other | 3 | 17% |
Unknown | 5 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 33% |
Unspecified | 1 | 6% |
Nursing and Health Professions | 1 | 6% |
Biochemistry, Genetics and Molecular Biology | 1 | 6% |
Physics and Astronomy | 1 | 6% |
Other | 1 | 6% |
Unknown | 7 | 39% |