Title |
Epigenetics and type II diabetes mellitus: underlying mechanisms of prenatal predisposition
|
---|---|
Published in |
Frontiers in Cell and Developmental Biology, May 2014
|
DOI | 10.3389/fcell.2014.00015 |
Pubmed ID | |
Authors |
J. David Sterns, Colin B. Smith, John R. Steele, Kimberly L. Stevenson, G. Ian Gallicano |
Abstract |
Type II diabetes mellitus (T2DM) is a widespread metabolic disorder characterized by insulin resistance precipitating abnormally high blood glucose levels. While the onset of T2DM is known to be the consequence of a multifactorial interplay with a strong genetic component, emerging research has demonstrated the additional role of a variety of epigenetic mechanisms in the development of this disorder. Heritable epigenetic modifications, such as DNA methylation and histone modifications, play a vital role in many important cellular processes, including pancreatic cellular differentiation and maintenance of normal β-cell function. Recent studies have found possible epigenetic mechanisms to explain observed risk factors, such as altered atherogenic lipid profiles, elevated body mass index (BMI), and impaired glucose tolerance (IGT), for later development of T2DM in children born to mothers experiencing both famine and hyperglycemic conditions. It is suggested that these epigenetic influences happen early during gestation and are less susceptible to the effects of postnatal environmental modification as was previously thought, highlighting the importance of early preventative measures in minimizing the global burden of T2DM. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Sweden | 1 | 1% |
Germany | 1 | 1% |
Unknown | 76 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 19 | 24% |
Student > Master | 14 | 18% |
Researcher | 12 | 15% |
Other | 5 | 6% |
Student > Postgraduate | 5 | 6% |
Other | 8 | 10% |
Unknown | 15 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 17 | 22% |
Medicine and Dentistry | 16 | 21% |
Agricultural and Biological Sciences | 12 | 15% |
Nursing and Health Professions | 8 | 10% |
Veterinary Science and Veterinary Medicine | 1 | 1% |
Other | 8 | 10% |
Unknown | 16 | 21% |