Title |
GPER Function in Breast Cancer: An Overview
|
---|---|
Published in |
Frontiers in endocrinology, May 2014
|
DOI | 10.3389/fendo.2014.00066 |
Pubmed ID | |
Authors |
Rosamaria Lappano, Assunta Pisano, Marcello Maggiolini |
Abstract |
The G-protein-coupled estrogen receptor-1 (GPER, formerly known as GPR30) has attracted increasing interest, considering its ability to mediate estrogenic signaling in different cell types, including the hormone-sensitive tumors like breast cancer. As observed for other GPCR-mediated responses, the activation of the epidermal growth factor receptor is a fundamental integration point in the biological action triggered by GPER. A wide number of natural and synthetic compounds, including estrogens and anti-estrogens, elicit stimulatory effects in breast cancer through GPER up-regulation and activation, suggesting that GPER function is associated with breast tumor progression and tamoxifen resistance. GPER has also been proposed as a candidate biomarker in triple-negative breast cancer, opening a novel scenario for a more comprehensive assessment of breast tumor patients. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | <1% |
Unknown | 103 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 23 | 22% |
Student > Bachelor | 15 | 14% |
Student > Master | 13 | 13% |
Student > Doctoral Student | 8 | 8% |
Researcher | 8 | 8% |
Other | 16 | 15% |
Unknown | 21 | 20% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 28 | 27% |
Agricultural and Biological Sciences | 24 | 23% |
Medicine and Dentistry | 11 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 8 | 8% |
Immunology and Microbiology | 2 | 2% |
Other | 6 | 6% |
Unknown | 25 | 24% |