Title |
M‐type K+ channels in peripheral nociceptive pathways
|
---|---|
Published in |
British Journal of Pharmacology, September 2017
|
DOI | 10.1111/bph.13978 |
Pubmed ID | |
Authors |
Xiaona Du, Haixia Gao, David Jaffe, Hailin Zhang, Nikita Gamper |
Abstract |
Pathological pain is a hyperexcitability disorder. Since the excitability of a neuron is set and controlled by a complement of ion channels it expresses, in order to understand and treat pain we need to develop a mechanistic insight into the key ion channels controlling excitability within the mammalian pain pathways, and how these ion channels are regulated and modulated in various physiological and pathophysiological settings. In this review we will discuss the emerging data on the expression in pain pathways, functional role and modulation of a family of voltage-gated K(+) channels called 'M channels' (KCNQ, Kv7). M channels are increasingly recognised as important players in controlling pain signaling, especially within the peripheral somatosensory system. We will also discuss therapeutic potential of M channels as analgesic drug targets. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 22% |
United States | 2 | 22% |
Unknown | 5 | 56% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 67% |
Scientists | 3 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 53 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 26% |
Researcher | 8 | 15% |
Student > Bachelor | 3 | 6% |
Student > Master | 3 | 6% |
Student > Doctoral Student | 2 | 4% |
Other | 8 | 15% |
Unknown | 15 | 28% |
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Pharmacology, Toxicology and Pharmaceutical Science | 6 | 11% |
Medicine and Dentistry | 4 | 8% |
Agricultural and Biological Sciences | 3 | 6% |
Other | 3 | 6% |
Unknown | 20 | 38% |