Title |
Rugged Large Volume Injection for Sensitive Capillary LC-MS Environmental Monitoring
|
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Published in |
Frontiers in Chemistry, August 2017
|
DOI | 10.3389/fchem.2017.00062 |
Pubmed ID | |
Authors |
Hanne Roberg-Larsen, Silvija Abele, Deniz Demir, Diana Dzabijeva, Sunniva F. Amundsen, Steven R. Wilson, Vadims Bartkevics, Elsa Lundanes |
Abstract |
A rugged and high throughput capillary column (cLC) LC-MS switching platform using large volume injection and on-line automatic filtration and filter back-flush (AFFL) solid phase extraction (SPE) for analysis of environmental water samples with minimal sample preparation is presented. Although narrow columns and on-line sample preparation are used in the platform, high ruggedness is achieved e.g., injection of 100 non-filtrated water samples did not result in a pressure rise/clogging of the SPE/capillary columns (inner diameter 300 μm). In addition, satisfactory retention time stability and chromatographic resolution were also features of the system. The potential of the platform for environmental water samples was demonstrated with various pharmaceutical products, which had detection limits (LOD) in the 0.05-12.5 ng/L range. Between-day and within-day repeatability of selected analytes were <20% RSD. |
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