Title |
FHL1C induces apoptosis in notch1-dependent T-ALL cells through an interaction with RBP-J
|
---|---|
Published in |
BMC Cancer, June 2014
|
DOI | 10.1186/1471-2407-14-463 |
Pubmed ID | |
Authors |
Wei Fu, Kai Wang, Jun-Long Zhao, Heng-Chao Yu, San-Zhong Li, Yan Lin, Liang Liang, Si-Yong Huang, Ying-Min Liang, Hua Han, Hong-Yan Qin |
Abstract |
Aberrantly activated Notch signaling has been found in more than 50% of patients with T-cell acute lymphoblastic leukemia (T-ALL). Current strategies that employ γ-secretase inhibitors (GSIs) to target Notch activation have not been successful. Many limitations, such as non-Notch specificity, dose-limiting gastrointestinal toxicity and GSI resistance, have prompted an urgent need for more effective Notch signaling inhibitors for T-ALL treatment. Human four-and-a-half LIM domain protein 1C (FHL1C) (KyoT2 in mice) has been demonstrated to suppress Notch activation in vitro, suggesting that FHL1C may be new candidate target in T-ALL therapy. However, the role of FHL1C in T-ALL cells remained unclear. |
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Country | Count | As % |
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Unknown | 2 | 100% |
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Scientists | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Unspecified | 8 | 42% |
Student > Ph. D. Student | 4 | 21% |
Researcher | 2 | 11% |
Student > Bachelor | 1 | 5% |
Student > Master | 1 | 5% |
Other | 0 | 0% |
Unknown | 3 | 16% |
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Immunology and Microbiology | 1 | 5% |
Other | 1 | 5% |
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