Title |
A diagnostic scale for Alzheimer’s disease based on cerebrospinal fluid biomarker profiles
|
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Published in |
Alzheimer's Research & Therapy, June 2014
|
DOI | 10.1186/alzrt267 |
Pubmed ID | |
Authors |
Sylvain Lehmann, Julien Dumurgier, Susanna Schraen, David Wallon, Frédéric Blanc, Eloi Magnin, Stéphanie Bombois, Olivier Bousiges, Dominique Campion, Benjamin Cretin, Constance Delaby, Didier Hannequin, Barbara Jung, Jacques Hugon, Jean-Louis Laplanche, Carole Miguet-Alfonsi, Katell Peoc’h, Nathalie Philippi, Muriel Quillard-Muraine, Bernard Sablonnière, Jacques Touchon, Olivier Vercruysse, Claire Paquet, Florence Pasquier, Audrey Gabelle |
Abstract |
The relevance of the cerebrospinal fluid (CSF) biomarkers for the diagnosis of Alzheimer's disease (AD) and related disorders is clearly established. However, the question remains on how to use these data, which are often heterogeneous (not all biomarkers being pathologic). The objective of this study is to propose to physicians in memory clinics a biologic scale of probabilities that the patient with cognitive impairments has an Alzheimer's disease (AD) pathologic process. |
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