Title |
Role of microRNA-146a in normal and malignant hematopoietic stem cell function
|
---|---|
Published in |
Frontiers in Genetics, July 2014
|
DOI | 10.3389/fgene.2014.00219 |
Pubmed ID | |
Authors |
Jimmy L. Zhao, Daniel T. Starczynowski |
Abstract |
Regulation of hematopoiesis is controlled by microRNAs (miRNAs). In this review, we focus on miR-146a, and its role in regulating normal and malignant hematopoiesis. miR-146a is a negative regulator of immune cell activation by repressing two targets, TRAF6 and IRAK1. Genetic deletion of miR-146a confirmed a role of miR-146a during innate immune signaling as well as for hematopoietic stem cell function. miR-146a is also implicated in the pathogenesis of human myelodysplastic syndromes (MDSs) as it is located within a commonly deleted region on chromosome 5, and miR-146a-deficient mice exhibit features of an MDS-like disease. With new insight into miR-146a through genetic and expression analyses, we highlight and discuss the recent advances in the understanding of miR-146a in physiological hematopoiesis during steady-state and inflammation, as well as in MDS. |
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