Title |
Furanodiene Induces Extrinsic and Intrinsic Apoptosis in Doxorubicin-Resistant MCF-7 Breast Cancer Cells via NF-κB-Independent Mechanism
|
---|---|
Published in |
Frontiers in Pharmacology, September 2017
|
DOI | 10.3389/fphar.2017.00648 |
Pubmed ID | |
Authors |
Zhang-Feng Zhong, Hai-Bing Yu, Chun-Ming Wang, Wen-An Qiang, Sheng-Peng Wang, Jin-Ming Zhang, Hua Yu, Liao Cui, Tie Wu, De-Qiang Li, Yi-Tao Wang |
Abstract |
Chemotherapy is used as a primary approach in cancer treatment after routine surgery. However, chemo-resistance tends to occur when chemotherapy is used clinically, resulting in poor prognosis and recurrence. Currently, Chinese medicine may provide insight into the design of new therapies to overcome chemo-resistance. Furanodiene, as a heat-sensitive sesquiterpene, is isolated from the essential oil of Rhizoma Curcumae. Even though mounting evidence claiming that furanodiene possesses anti-cancer activities in various types of cancers, the underlying mechanisms against chemo-resistant cancer are not fully clear. Our study found that furanodiene could display anti-cancer effects by inhibiting cell viability, inducing cell cytotoxicity, and suppressing cell proliferation in doxorubicin-resistant MCF-7 breast cancer cells. Furthermore, furanodiene preferentially causes apoptosis by interfering with intrinsic/extrinsic-dependent and NF-κB-independent pathways in doxorubicin-resistant MCF-7 cells. These observations also prompt that furanodiene may be developed as a promising natural product for multidrug-resistant cancer therapy in the future. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 27 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 26% |
Student > Bachelor | 4 | 15% |
Student > Master | 3 | 11% |
Professor > Associate Professor | 3 | 11% |
Professor | 2 | 7% |
Other | 5 | 19% |
Unknown | 3 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 7 | 26% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 22% |
Agricultural and Biological Sciences | 4 | 15% |
Engineering | 2 | 7% |
Chemistry | 2 | 7% |
Other | 3 | 11% |
Unknown | 3 | 11% |