Title |
Modulation of dendritic cell functions by viral IL-10 encoded by human cytomegalovirus
|
---|---|
Published in |
Frontiers in Microbiology, July 2014
|
DOI | 10.3389/fmicb.2014.00337 |
Pubmed ID | |
Authors |
Selmir Avdic, Brian P. McSharry, Barry Slobedman |
Abstract |
Human cytomegalovirus (HCMV), a clinically important β-herpesvirus, is a master of evasion and modulation of the host immune system, including inhibition of a number of dendritic cell (DC) functions. DCs play a central role in co-ordination of the immune response against pathogens and any disturbance of DCs functions can result in a cascade effect on a range of immune cells. Recently, the HCMV gene UL111A, which encodes viral homologs of human interleukin 10, has been identified as a strong suppressor of a number of DCs functions. In this mini review, we focus on HCMV-encoded viral IL-10-mediated inhibitory effects on DCs and implications for the development of an effective HCMV vaccine. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 37 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 19% |
Student > Doctoral Student | 6 | 16% |
Student > Bachelor | 5 | 14% |
Student > Master | 5 | 14% |
Student > Ph. D. Student | 4 | 11% |
Other | 4 | 11% |
Unknown | 6 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 14 | 38% |
Immunology and Microbiology | 6 | 16% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Medicine and Dentistry | 4 | 11% |
Social Sciences | 2 | 5% |
Other | 1 | 3% |
Unknown | 6 | 16% |