Joo-In Park, Hae-Rahn Bae, Chang Gun Kim, Valentin A. Stonik, Jong-Young Kwak
Abstract
Many marine triterpene glycosides have in vitro and in vivo activities with very low toxicity, suggesting that they are suitable agents for the prevention and treatment of different diseases, particularly cancer. However, the molecular mechanisms of action of natural marine compounds in cancer, immune, and other various cells are not fully known. This review focuses on the structural characteristics of marine triterpene glycosides and how these affect their biological activities and molecular mechanisms. In particular, the membranotropic and membranolytic activities of frondoside A and cucumariosides from sea cucumbers and their ability to induce cytotoxicity and apoptosis have been discussed, with a focus on structure-activity relationships. In addition, the structural characteristics and antitumor effects of stichoposide C and stichoposide D have been reviewed along with underlying their molecular mechanisms.
Pharmacology, Toxicology and Pharmaceutical Science
7
12%
Biochemistry, Genetics and Molecular Biology
4
7%
Business, Management and Accounting
2
4%
Other
6
11%
Unknown
19
33%
Attention Score in Context
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2023.
All research outputs
#7,040,496
of 24,662,675 outputs
Outputs from Frontiers in Chemistry
#522
of 6,530 outputs
Outputs of similar age
#66,075
of 243,810 outputs
Outputs of similar age from Frontiers in Chemistry
#7
of 34 outputs
Altmetric has tracked 24,662,675 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 6,530 research outputs from this source. They receive a mean Attention Score of 2.2. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 243,810 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.
