Title |
Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration
|
---|---|
Published in |
BMC Genomics, September 2014
|
DOI | 10.1186/1471-2164-15-726 |
Pubmed ID | |
Authors |
Yogesh Saini, Hong Dang, Alessandra Livraghi-Butrico, Elizabeth J Kelly, Lisa C Jones, Wanda K O’Neal, Richard C Boucher |
Abstract |
Defects in airway mucosal defense, including decreased mucus clearance, contribute to the pathogenesis of human chronic obstructive pulmonary diseases. Scnn1b-Tg mice, which exhibit chronic airway surface dehydration from birth, can be used as a model to study the pathogenesis of muco-obstructive lung disease across developmental stages. To identify molecular signatures associated with obstructive lung disease in this model, gene expression analyses were performed on whole lung and purified lung macrophages collected from Scnn1b-Tg and wild-type (WT) littermates at four pathologically relevant time points. Macrophage gene expression at 6 weeks was evaluated in mice from a germ-free environment to understand the contribution of microbes to disease development. |
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Country | Count | As % |
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Austria | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
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Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
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Unknown | 46 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 12 | 26% |
Student > Ph. D. Student | 11 | 24% |
Student > Bachelor | 7 | 15% |
Student > Doctoral Student | 3 | 7% |
Professor | 2 | 4% |
Other | 6 | 13% |
Unknown | 5 | 11% |
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Engineering | 3 | 7% |
Other | 5 | 11% |
Unknown | 8 | 17% |