Title |
Immunity-related genes in Ixodes scapularis—perspectives from genome information
|
---|---|
Published in |
Frontiers in Cellular and Infection Microbiology, August 2014
|
DOI | 10.3389/fcimb.2014.00116 |
Pubmed ID | |
Authors |
Alexis A. Smith, Utpal Pal |
Abstract |
Ixodes scapularis, commonly known as the deer tick, transmits a wide array of human and animal pathogens including Borrelia burgdorferi. Despite substantial advances in our understanding of immunity in model arthropods, including other disease vectors, precisely how I. scapularis immunity functions and influences persistence of invading pathogens remains largely unknown. This review provides a comprehensive analysis of the recently sequenced I. scapularis genome for the occurrence of immune-related genes and related pathways. We will also discuss the potential influence of immunity-related genes on the persistence of tick-borne pathogens with an emphasis on the Lyme disease pathogen B. burgdorferi. Further enhancement of our knowledge of tick immune responses is critical to understanding the molecular basis of the persistence of tick-borne pathogens and development of novel interventions against the relevant infections. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 2% |
Czechia | 1 | 1% |
Unknown | 91 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 23 | 24% |
Researcher | 17 | 18% |
Student > Bachelor | 13 | 14% |
Student > Master | 6 | 6% |
Student > Doctoral Student | 4 | 4% |
Other | 17 | 18% |
Unknown | 14 | 15% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 25 | 27% |
Biochemistry, Genetics and Molecular Biology | 20 | 21% |
Immunology and Microbiology | 7 | 7% |
Medicine and Dentistry | 6 | 6% |
Veterinary Science and Veterinary Medicine | 4 | 4% |
Other | 13 | 14% |
Unknown | 19 | 20% |