Title |
Effects of Anterior Capsulotomy on Decision Making in Patients with Refractory Obsessive–Compulsive Disorder
|
---|---|
Published in |
Frontiers in Psychology, October 2017
|
DOI | 10.3389/fpsyg.2017.01814 |
Pubmed ID | |
Authors |
Chencheng Zhang, Yilin Chen, Shuaiwei Tian, Tao Wang, Yile Xie, Haiyan Jin, Guozhen Lin, Hengfen Gong, Kristina Zeljic, Bomin Sun, Tianming Yang, Shikun Zhan |
Abstract |
Despite various lines of evidence implicating impaired decision-making ability in individuals with obsessive-compulsive disorder (OCD), neuropsychological investigation has generated inconsistent findings. Although the cortico-striato-thalamo-cortical (CSTC) circuitry has been suggested, the involvement of the cortex has not yet been fully demonstrated. Moreover, it is unknown whether surgical intervention on the CSTC circuitry results in a predicted improvement of decision-making ability of OCD. Here we present a study of decision making based on the Iowa Gambling Task (IGT) to investigate decision making in a large sample of individuals with treatment-resistant OCD with and without anterior capsulotomy (AC). Task performance was evaluated in healthy subjects, individuals with OCD that had not undergone surgery, and postsurgical OCD patients with AC. The latter group was further divided into a short-term postsurgical group and a long-term postsurgical group. We found that the OCD patients without surgery performed significantly worse than the healthy controls on the IGT. There were no significant differences in decision-making between the presurgical OCD patients and those at the short-term postsurgical follow-up. Decision-making ability of the long-term postsurgical OCD patients was improved to the level comparable to that of healthy controls. All clinical symptoms (OCD, depression, and anxiety) assessed by psychiatric rating scales were significantly alleviated post-surgically, but exhibited no correlation with their IGT task performance. Our findings provide strong evidence that OCD is linked to impairments in decision-making ability; that impaired CSTC circuitry function is directly involved in the manifestation of OCD; and that AC related improvements in cognitive functions are caused by long-term plasticity in the brain circuitry. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 40% |
Switzerland | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 47 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 6 | 13% |
Researcher | 5 | 11% |
Student > Ph. D. Student | 4 | 9% |
Student > Bachelor | 2 | 4% |
Student > Postgraduate | 2 | 4% |
Other | 7 | 15% |
Unknown | 21 | 45% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 6 | 13% |
Neuroscience | 5 | 11% |
Medicine and Dentistry | 4 | 9% |
Nursing and Health Professions | 2 | 4% |
Social Sciences | 2 | 4% |
Other | 5 | 11% |
Unknown | 23 | 49% |