Title |
A non-canonical landscape of the microRNA system
|
---|---|
Published in |
Frontiers in Genetics, September 2014
|
DOI | 10.3389/fgene.2014.00337 |
Pubmed ID | |
Authors |
Gabriel A Cipolla |
Abstract |
Microribonucleic acids, best known as microRNAs or miRNAs, are small, non-coding RNAs with important regulatory roles in eukaryotic cells. Here, I present a broad review on highly relevant but generally non-depicted features of miRNAs, among which stand out the non-conventional miRNA seed sites, the unusual messenger RNA (mRNA) target regions, the non-canonical miRNA-guided mechanisms of gene expression regulation, and the recently identified new class of miRNA ligands. Furthermore, I address the miRNA uncommon genomic location, transcription, and subcellular localization. Altogether, these unusual features and roles place the miRNA system as a very diverse, complex, and intriguing biological mechanism. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 1 | 17% |
France | 1 | 17% |
Switzerland | 1 | 17% |
Unknown | 3 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 83% |
Scientists | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Spain | 3 | 3% |
Brazil | 2 | 2% |
Germany | 1 | <1% |
France | 1 | <1% |
Denmark | 1 | <1% |
Egypt | 1 | <1% |
Unknown | 98 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 24 | 22% |
Student > Master | 22 | 21% |
Researcher | 20 | 19% |
Student > Doctoral Student | 11 | 10% |
Student > Bachelor | 7 | 7% |
Other | 16 | 15% |
Unknown | 7 | 7% |
Readers by discipline | Count | As % |
---|---|---|
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Biochemistry, Genetics and Molecular Biology | 33 | 31% |
Medicine and Dentistry | 8 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Immunology and Microbiology | 2 | 2% |
Other | 8 | 7% |
Unknown | 10 | 9% |