Title |
A possible link between BDNF and mTOR in control of food intake
|
---|---|
Published in |
Frontiers in Psychology, September 2014
|
DOI | 10.3389/fpsyg.2014.01093 |
Pubmed ID | |
Authors |
Nobuyuki Takei, Kazuo Furukawa, Osamu Hanyu, Hirohito Sone, Hiroyuki Nawa |
Abstract |
Food intake is intricately regulated by glucose, amino acids, hormones, neuropeptides, and trophic factors through a neural circuit in the hypothalamus. Brain-derived neurotrophic factor (BDNF), the most prominent neurotrophic factor in the brain, regulates differentiation, maturation, and synaptic plasticity throughout life. Among its many roles, BDNF exerts an anorexigenic function in the brain. However, the intracellular signaling induced by BDNF to control food intake is not fully understood. One candidate for the molecule involved in transducing the anorexigenic activity of BDNF is the mammalian target of rapamycin (mTOR). mTOR senses extracellular amino acids, glucose, growth factors, and neurotransmitters, and regulates anabolic reactions response to these signals. Activated mTOR increases protein and lipid synthesis and inhibits protein degradation. In the hypothalamus, mTOR activation is thought to reduce food intake. Here we summarize recent findings regarding BDNF- and mTOR-mediated feeding control, and propose a link between these molecules in eating behavior. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 1% |
Spain | 1 | 1% |
United States | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 77 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 17% |
Researcher | 7 | 9% |
Student > Master | 7 | 9% |
Student > Bachelor | 7 | 9% |
Student > Doctoral Student | 6 | 7% |
Other | 20 | 25% |
Unknown | 20 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 21% |
Medicine and Dentistry | 11 | 14% |
Neuroscience | 9 | 11% |
Biochemistry, Genetics and Molecular Biology | 7 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Other | 11 | 14% |
Unknown | 22 | 27% |