Title |
Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections
|
---|---|
Published in |
Frontiers in immunology, October 2017
|
DOI | 10.3389/fimmu.2017.01311 |
Pubmed ID | |
Authors |
Hesham M. Shehata, Andrew J. Murphy, Man kit Sam Lee, Clair M. Gardiner, Suzanne M. Crowe, Shomyseh Sanjabi, David K. Finlay, Clovis Steve Palmer |
Abstract |
The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming through the use of glycolysis and fatty-acid oxidation (sugar or fat) regulates the capacity of immune cells to mount robust and effective immune responses. We will also discuss how fine-tuning sugar and fat metabolism may be exploited as a novel immunotherapeutic strategy to fight viral infections or improve vaccine efficacy. |
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Geographical breakdown
Country | Count | As % |
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United States | 40 | 10% |
United Kingdom | 22 | 6% |
Spain | 11 | 3% |
India | 7 | 2% |
France | 6 | 2% |
Ireland | 6 | 2% |
Brazil | 5 | 1% |
Indonesia | 4 | 1% |
Canada | 4 | 1% |
Other | 49 | 12% |
Unknown | 243 | 61% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 245 | 62% |
Scientists | 112 | 28% |
Practitioners (doctors, other healthcare professionals) | 24 | 6% |
Science communicators (journalists, bloggers, editors) | 10 | 3% |
Unknown | 6 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 105 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 23 | 22% |
Researcher | 20 | 19% |
Student > Bachelor | 12 | 11% |
Student > Master | 8 | 8% |
Student > Doctoral Student | 7 | 7% |
Other | 19 | 18% |
Unknown | 16 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 27 | 26% |
Biochemistry, Genetics and Molecular Biology | 17 | 16% |
Agricultural and Biological Sciences | 16 | 15% |
Medicine and Dentistry | 7 | 7% |
Chemistry | 3 | 3% |
Other | 13 | 12% |
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