Title |
The role of hormones on Toxoplasma gondii infection: a systematic review
|
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Published in |
Frontiers in Microbiology, October 2014
|
DOI | 10.3389/fmicb.2014.00503 |
Pubmed ID | |
Authors |
María de la Luz Galván-Ramírez, Adrián Fernando Gutiérrez-Maldonado, Fabiola Verduzco-Grijalva, Judith Marcela Dueñas Jiménez |
Abstract |
Toxoplasma gondii is the causal agent of toxoplasmosis in which one third of the world's population has been infected. In pregnant women, it may cause abortion and severe damage to the fetal central nervous system. During pregnancy, the prevalence of toxoplasmosis increases throughout the second and third quarter of gestation, simultaneously progesterone and 17β-estradiol also increase. Thus, it has been suggested that these hormones can aggravate or reduce parasite reproduction. The aim of this study was reviewing the relationship between hormones and infection caused by T. gondii in several experimental animal models and humans, focused mainly on: (a) congenital transmission, (b) parasite reproduction, (c) strain virulence, (d) levels of hormone in host induced by T. gondii infection, and (e) participation of hormone receptors in T. gondii infection. Are the hormones specific modulators of T. gondii infection? A systematic review methodology was used to consult several databases (Pub Med, Lilacs, Medline, Science direct, Scielo, Ebsco, Sprinker, Wiley, and Google Scholar) dated from September, 2013 to March, 2014. |
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