Title |
Pathophysiology and treatment of cardiac amyloidosis
|
---|---|
Published in |
Nature Reviews Cardiology, October 2014
|
DOI | 10.1038/nrcardio.2014.165 |
Pubmed ID | |
Authors |
Morie A. Gertz, Angela Dispenzieri, Taimur Sher |
Abstract |
Amyloid cardiomyopathy should be suspected in any patient who presents with heart failure and preserved ejection fraction. In patients with echocardiographic evidence of ventricular thickening and without a clear history of hypertension, infiltrative cardiomyopathy should be considered. If imaging suggests the presence of amyloid deposits, confirmation by biopsy is required, although endomyocardial biopsy is generally not necessary. Assessment of aspirated subcutaneous fat and bone-marrow biopsy samples verifies the diagnosis in 40-80% of patients, dependent on the type of amyloidosis. Mass spectroscopy can be used to determine the protein subunit and classify the disease as immunoglobulin light-chain amyloidosis or transthyretin-related amyloidosis associated with mutant or wild-type TTR (formerly known as familial amyloid cardiomyopathy and senile cardiac amyloidosis, respectively). In this Review, we discuss the characteristics of cardiac amyloidosis, and present a structured approach to both the assessment of patients and treatment with emerging therapies and organ transplantation. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 29% |
Unknown | 5 | 71% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 43% |
Scientists | 3 | 43% |
Practitioners (doctors, other healthcare professionals) | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | <1% |
United States | 1 | <1% |
Sweden | 1 | <1% |
Unknown | 175 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 29 | 16% |
Student > Ph. D. Student | 17 | 10% |
Student > Postgraduate | 17 | 10% |
Student > Doctoral Student | 16 | 9% |
Other | 14 | 8% |
Other | 43 | 24% |
Unknown | 42 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 88 | 49% |
Biochemistry, Genetics and Molecular Biology | 11 | 6% |
Agricultural and Biological Sciences | 9 | 5% |
Immunology and Microbiology | 3 | 2% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
Other | 15 | 8% |
Unknown | 49 | 28% |