Title |
Neutrophil-Derived Cytokines: Facts Beyond Expression
|
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Published in |
Frontiers in immunology, October 2014
|
DOI | 10.3389/fimmu.2014.00508 |
Pubmed ID | |
Authors |
Cristina Tecchio, Alessandra Micheletti, Marco A. Cassatella |
Abstract |
Polymorphonuclear neutrophils, besides their involvement in primary defense against infections - mainly through phagocytosis, generation of toxic molecules, release of enzymes, and formation of extracellular traps - are also becoming increasingly important for their contribution to the fine regulation in development of inflammatory and immune responses. These latter functions of neutrophils occur, in part, via their de novo production and release of a large variety of cytokines, including chemotactic cytokines (chemokines). Accordingly, the improvement in technologies for molecular and functional cell analysis, along with concomitant advances in cell purification techniques, have allowed the identification of a continuously growing list of neutrophil-derived cytokines, as well as the characterization of their biological implications in vitro and/or in vivo. This short review summarizes crucial concepts regarding the modalities of expression, release, and regulation of neutrophil-derived cytokines. It also highlights examples illustrating the potential implications of neutrophil-derived cytokines according to recent observations made in humans and/or in experimental animal models. |
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Country | Count | As % |
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Netherlands | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 3 | <1% |
Netherlands | 2 | <1% |
France | 1 | <1% |
Germany | 1 | <1% |
India | 1 | <1% |
Australia | 1 | <1% |
Unknown | 733 | 99% |
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Student > Ph. D. Student | 163 | 22% |
Student > Master | 101 | 14% |
Researcher | 93 | 13% |
Student > Bachelor | 74 | 10% |
Student > Doctoral Student | 41 | 6% |
Other | 107 | 14% |
Unknown | 163 | 22% |
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Immunology and Microbiology | 126 | 17% |
Agricultural and Biological Sciences | 125 | 17% |
Biochemistry, Genetics and Molecular Biology | 110 | 15% |
Medicine and Dentistry | 97 | 13% |
Neuroscience | 16 | 2% |
Other | 77 | 10% |
Unknown | 191 | 26% |