Title |
Chronological differential effects of pro-inflammatory cytokines on RANKL-induced osteoclast differentiation of canine bone marrow-derived macrophages
|
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Published in |
Journal of Veterinary Medical Science, November 2017
|
DOI | 10.1292/jvms.17-0393 |
Pubmed ID | |
Authors |
Suranji WIJEKOON, Eugene C. BWALYA, FANG Jing, KIM Sangho, Kenji HOSOYA, Masahiro OKUMURA |
Abstract |
The aim of this study was to investigate osteoclastogenic properties of inflammatory cytokines at different time-points of osteoclastogenesis. Bone marrow-derived macrophages from five healthy dogs were stimulated with the macrophage colony-stimulating factor, receptor activator of nuclear factor-κB ligand and inflammatory cytokines such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-17. Osteoclasts (OC) formation and function were enhanced with TNF-α regardless of temporal differences. But in contrast, IL-1β suppressed the osteoclastogenesis at early phase of the process while upregulating at the late phase. Furthermore, differentiation of OC precursors into OC was suppressed at high concentrations of IL-17. Collectively, the results revealed that suppressing TNF-α would be a promising strategy to inhibit inflammation-associated bone destruction in dogs. |
X Demographics
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Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Doctoral Student | 3 | 20% |
Other | 2 | 13% |
Student > Master | 2 | 13% |
Professor | 1 | 7% |
Student > Bachelor | 1 | 7% |
Other | 2 | 13% |
Unknown | 4 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Veterinary Science and Veterinary Medicine | 4 | 27% |
Biochemistry, Genetics and Molecular Biology | 2 | 13% |
Immunology and Microbiology | 2 | 13% |
Nursing and Health Professions | 1 | 7% |
Agricultural and Biological Sciences | 1 | 7% |
Other | 1 | 7% |
Unknown | 4 | 27% |