Title |
Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment
|
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Published in |
Frontiers in Behavioral Neuroscience, October 2014
|
DOI | 10.3389/fnbeh.2014.00368 |
Pubmed ID | |
Authors |
Shinae Kwak, Namjung Huh, Ji-Seon Seo, Jung-Eun Lee, Pyung-Lim Han, Min W. Jung |
Abstract |
In order to investigate roles of dopamine receptor subtypes in reward-based learning, we examined choice behavior of dopamine D1 and D2 receptor-knockout (D1R-KO and D2R-KO, respectively) mice in an instrumental learning task with progressively increasing reversal frequency and a dynamic two-armed bandit task. Performance of D2R-KO mice was progressively impaired in the former as the frequency of reversal increased and profoundly impaired in the latter even with prolonged training, whereas D1R-KO mice showed relatively minor performance deficits. Choice behavior in the dynamic two-armed bandit task was well explained by a hybrid model including win-stay-lose-switch and reinforcement learning terms. A model-based analysis revealed increased win-stay, but impaired value updating and decreased value-dependent action selection in D2R-KO mice, which were detrimental to maximizing rewards in the dynamic two-armed bandit task. These results suggest an important role of dopamine D2 receptors in learning from past choice outcomes for rapid adjustment of choice behavior in a dynamic and uncertain environment. |
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China | 1 | 1% |
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United States | 1 | 1% |
Unknown | 63 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 16 | 23% |
Student > Ph. D. Student | 15 | 22% |
Student > Bachelor | 8 | 12% |
Student > Master | 6 | 9% |
Student > Doctoral Student | 3 | 4% |
Other | 9 | 13% |
Unknown | 12 | 17% |
Readers by discipline | Count | As % |
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Psychology | 7 | 10% |
Medicine and Dentistry | 4 | 6% |
Social Sciences | 4 | 6% |
Other | 7 | 10% |
Unknown | 17 | 25% |