Title |
NF-κβ: A Potential Target in the Management of Vascular Complications of Diabetes
|
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Published in |
Frontiers in Pharmacology, November 2017
|
DOI | 10.3389/fphar.2017.00798 |
Pubmed ID | |
Authors |
Sachin V Suryavanshi, Yogesh A Kulkarni |
Abstract |
Diabetes is a metabolic disorder affecting large percentage of population worldwide. NF-κβ plays key role in pathogenesis of vascular complications of diabetes. Persistent hyperglycemia activates NF-κβ that triggers expression of various cytokines, chemokines and cell adhesion molecules. Over-expression of TNF-α, interleukins, TGF-β, Bcl2 and other pro-inflammatory proteins and pro-apoptotic genes by NF-κβ is key risk factor in vascular dysfunction. NF-κβ over-expression also triggers calcification of endothelial cells leading to endothelial dysfunction and further vascular complications. Inhibition of NF-κβ pro-inflammatory pathway is upcoming novel target for management of vascular complications of diabetes. Various natural and synthetic inhibitors of NF-κβ have been studied in management of diabetic complications. Recent preclinical and clinical studies validate NF-κβ as promising target in the management of vascular complications of diabetes. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 281 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 26 | 9% |
Student > Master | 26 | 9% |
Student > Bachelor | 24 | 9% |
Other | 18 | 6% |
Student > Doctoral Student | 17 | 6% |
Other | 54 | 19% |
Unknown | 116 | 41% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 51 | 18% |
Biochemistry, Genetics and Molecular Biology | 37 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 23 | 8% |
Agricultural and Biological Sciences | 7 | 2% |
Immunology and Microbiology | 6 | 2% |
Other | 31 | 11% |
Unknown | 126 | 45% |