The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
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Mendeley readers
Attention Score in Context
| Title |
Discovery and Preclinical Profiling of 3‑[4-(Morpholin-4-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor
|
|---|---|
| Published in |
Journal of Medicinal Chemistry, November 2014
|
| DOI | 10.1021/jm5014055 |
| Pubmed ID | |
| Authors |
Jaclyn L. Henderson, Bethany L. Kormos, Matthew M. Hayward, Karen J. Coffman, Jayasankar Jasti, Ravi G. Kurumbail, Travis T. Wager, Patrick R. Verhoest, G. Stephen Noell, Yi Chen, Elie Needle, Zdenek Berger, Stefanus J. Steyn, Christopher Houle, Warren D. Hirst, Paul Galatsis |
| Abstract |
Leucine rich repeat kinase 2 (LRRK2) has been genetically linked to Parkinson's disease (PD) by genome-wide association studies (GWAS). The most common LRRK2 mutation, but relatively rare in the total population, G2019S gives rise to increased kinase activity, thus LRRK2 kinase inhibitors are potentially useful in the treatment of PD. We herein disclose the discovery and optimization of a novel series of potent LRRK2 inhibitors, focusing on improving kinome selectivity using a surrogate crystallography approach. This resulted in identification of 14 (PF-06447475), a highly potent, brain penetrant and selective LRRK2 inhibitor which has been further profiled in in vivo safety and pharmacodynamic studies. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 121 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 30 | 24% |
| Student > Ph. D. Student | 27 | 22% |
| Student > Master | 12 | 10% |
| Professor > Associate Professor | 9 | 7% |
| Student > Bachelor | 9 | 7% |
| Other | 19 | 15% |
| Unknown | 19 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 29 | 23% |
| Biochemistry, Genetics and Molecular Biology | 21 | 17% |
| Agricultural and Biological Sciences | 15 | 12% |
| Neuroscience | 12 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 8 | 6% |
| Other | 13 | 10% |
| Unknown | 27 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 May 2024.
All research outputs
#4,648,295
of 24,657,405 outputs
Outputs from Journal of Medicinal Chemistry
#6,652
of 22,848 outputs
Outputs of similar age
#62,153
of 371,306 outputs
Outputs of similar age from Journal of Medicinal Chemistry
#43
of 151 outputs
Altmetric has tracked 24,657,405 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 22,848 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 371,306 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 151 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.