Title |
Deciphering the heterogeneity in DNA methylation patterns during stem cell differentiation and reprogramming
|
---|---|
Published in |
BMC Genomics, November 2014
|
DOI | 10.1186/1471-2164-15-978 |
Pubmed ID | |
Authors |
Xiaojian Shao, Cuiyun Zhang, Ming-An Sun, Xuemei Lu, Hehuang Xie |
Abstract |
Human induced pluripotent stem cells (iPSCs) have a wide range of applications throughout the fields of basic research, disease modeling and drug screening. Epigenetic instable iPSCs with aberrant DNA methylation may divide and differentiate into cancer cells. Unfortunately, little effort has been taken to compare the epigenetic variation in iPSCs with that in differentiated cells. Here, we developed an analytical procedure to decipher the DNA methylation heterogeneity of mixed cells and further exploited it to quantitatively assess the DNA methylation variation in the methylomes of adipose-derived stem cells (ADS), mature adipocytes differentiated from ADS cells (ADS-adipose) and iPSCs reprogrammed from ADS cells (ADS-iPSCs). |
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