Title |
Neutrophils in Gliomas
|
---|---|
Published in |
Frontiers in immunology, October 2017
|
DOI | 10.3389/fimmu.2017.01349 |
Pubmed ID | |
Authors |
Matteo Massara, Pasquale Persico, Ornella Bonavita, Valeria Mollica Poeta, Massimo Locati, Matteo Simonelli, Raffaella Bonecchi |
Abstract |
Neutrophils are the most abundant white blood cells and are the first recruited to inflammatory sites. Neutrophils are an important component of the tumor stroma and can exert both anti-tumoral and pro-tumoral activities, depending on their maturation and activation state. In human gliomas, the number of circulating and infiltrating neutrophils correlates with the severity of the disease, indicating a prognostic and possible pro-tumoral role for these leukocytes. In glioma preclinical models, neutrophils promote tumor growth and orchestrate the resistance to anti-angiogenic therapies. Nevertheless, recent data indicate that neutrophils can be activated to directly kill tumor cells or to orchestrate the anti-tumoral response. Here, we review current knowledge about the role of neutrophils in glioma and their possible involvement in new strategies to improve current cancer therapies. |
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Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 133 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 25 | 19% |
Student > Bachelor | 15 | 11% |
Student > Master | 13 | 10% |
Student > Postgraduate | 12 | 9% |
Researcher | 10 | 8% |
Other | 17 | 13% |
Unknown | 41 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 26 | 20% |
Biochemistry, Genetics and Molecular Biology | 20 | 15% |
Immunology and Microbiology | 12 | 9% |
Neuroscience | 8 | 6% |
Agricultural and Biological Sciences | 6 | 5% |
Other | 11 | 8% |
Unknown | 50 | 38% |