Title |
Mitochondrial metabolism and the control of vascular smooth muscle cell proliferation
|
---|---|
Published in |
Frontiers in Cell and Developmental Biology, December 2014
|
DOI | 10.3389/fcell.2014.00072 |
Pubmed ID | |
Authors |
Mario Chiong, Benjamín Cartes-Saavedra, Ignacio Norambuena-Soto, David Mondaca-Ruff, Pablo E. Morales, Marina García-Miguel, Rosemarie Mellado |
Abstract |
Differentiation and dedifferentiation of vascular smooth muscle cells (VSMCs) are essential processes of vascular development. VSMC have biosynthetic, proliferative, and contractile roles in the vessel wall. Alterations in the differentiated state of the VSMC play a critical role in the pathogenesis of a variety of cardiovascular diseases, including atherosclerosis, hypertension, and vascular stenosis. This review provides an overview of the current state of knowledge of molecular mechanisms involved in the control of VSMC proliferation, with particular focus on mitochondrial metabolism. Mitochondrial activity can be controlled by regulating mitochondrial dynamics, i.e., mitochondrial fusion and fission, and by regulating mitochondrial calcium handling through the interaction with the endoplasmic reticulum (ER). Alterations in both VSMC proliferation and mitochondrial function can be triggered by dysregulation of mitofusin-2, a small GTPase associated with mitochondrial fusion and mitochondrial-ER interaction. Several lines of evidence highlight the relevance of mitochondrial metabolism in the control of VSMC proliferation, indicating a new area to be explored in the treatment of vascular diseases. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Unknown | 143 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 32 | 22% |
Student > Bachelor | 22 | 15% |
Researcher | 17 | 12% |
Student > Master | 15 | 10% |
Student > Doctoral Student | 9 | 6% |
Other | 19 | 13% |
Unknown | 30 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 34 | 24% |
Agricultural and Biological Sciences | 29 | 20% |
Medicine and Dentistry | 26 | 18% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 3% |
Neuroscience | 5 | 3% |
Other | 14 | 10% |
Unknown | 31 | 22% |