Title |
Local cytokine transcription in naïve and previously infected sheep and lambs following challenge with Teladorsagia circumcincta
|
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Published in |
BMC Veterinary Research, April 2014
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DOI | 10.1186/1746-6148-10-87 |
Pubmed ID | |
Authors |
Nicola M Craig, David W Smith, Judith A Pate, Ivan W Morrison, Pamela A Knight |
Abstract |
The abomasal helminth Teladorsagia circumcincta is one of the most economically important parasites affecting sheep in temperate regions. Infection is particularly detrimental to lambs, in which it can cause pronounced morbidity and severe production losses. Due to the spreading resistance of this parasite to all classes of anthelmintic drugs, teladorsagiosis is having an increasingly severe impact on the sheep industry with significant implications for sheep welfare. Protective immunity develops slowly, wanes rapidly and does not appear to be as effective in young lambs. To investigate the development of immunity to T. circumcincta in sheep and lambs, we used cytokine transcript profiling to examine differences in the abomasal mucosa and gastric lymph node of naïve and previously infected sheep and lambs following challenge. |
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Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Science communicators (journalists, bloggers, editors) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 33 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 27% |
Other | 4 | 12% |
Researcher | 4 | 12% |
Student > Bachelor | 2 | 6% |
Lecturer | 2 | 6% |
Other | 3 | 9% |
Unknown | 9 | 27% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 8 | 24% |
Veterinary Science and Veterinary Medicine | 6 | 18% |
Medicine and Dentistry | 5 | 15% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Immunology and Microbiology | 1 | 3% |
Other | 1 | 3% |
Unknown | 10 | 30% |